The effect of blood pressure on pulse wave velocity (PWV) is well established. However, PWV variability with acute hemodynamic\nchanges has not been examined in the clinical setting. The aim of the present study is to investigate the effect of hemodynamic\nchanges on PWV in patients who undergo cardiothoracic surgery. Using data from 25 patients, we determined blood pressure\n(BP), heart rate (HR), and the left ventricular outflow tract (LVOT) velocity-time integral. By superimposing the radial arterial\nwaveform on the continuous wave Doppler waveform of the LVOT, obtained by transesophageal echo, we were able to determine\npulse transit time and to calculatePWV, stroke volume (SV), cardiac output (CO), and systemic vascular resistance (SVR). Increases\nin BP,HR, and SVR were associated with higher values forPWV. In contrast increases in SV were associated with decreases inPWV.\nChanges in CO were not significantly associated with PWV.
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